The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage

Abstract excerpt

Significance The TGFβ signaling pathway is activated when TGFβ ligands induce formation of TGFβRI and TGFβRII receptor complexes. However, loss of TGFβRI in mouse cartilage led to more severe defects than did loss of TGFβRII. Most of the defects were rescued by deletion of the BMP receptor ACVRL1, suggesting that a major role of TGFβRI in cartilage development is to suppress BMP signaling by ACVRL1. TGFβRI...

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