Article
Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage.
Genes & development - 1 Sept 1997
Zou H, Wieser R, Massagué J, Niswander L
Abstract excerpt
The bone morphogenetic proteins (BMPs), TGF beta superfamily members, play diverse roles in embryogenesis, but how the BMPs exert their action is unclear and how different BMP receptors (BMPRs) contribute to this process is not known. Here we demonstrate that the two type I BMPRs, BMPR-IA and BMPR-IB, regulate distinct processes during chick limb development. BmpR-IB expression in the embryonic limb prefigures...
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