Article
Familial acute lymphoblastic leukemia.
[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jul 2016
Moriyama Takaya
Abstract excerpt
Somatically acquired genomic alterations have been recognized as key hallmarks inducing acute lymphoblastic leukemia (ALL), though recent knowledge acquired from genome-wide association study (GWAS) has revealed that inherited genetic variations (germline) are associated with ALL susceptibility as well as disease onset. The proportion of ALL cases attributable to an inherited genetic predisposition has been...
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