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Article

Inherited platelet dysfunction and hematopoietic transcription factor mutations.

Platelets - 1 Jan 2017

Songdej Natthapol, Rao A Koneti

Abstract excerpt

Transcription factors (TFs) are proteins that bind to specific DNA sequences and regulate expression of genes. The molecular and genetic mechanisms in most patients with inherited platelet dysfunction are unknown. There is now increasing evidence that mutations in hematopoietic TFs are an important underlying cause for the defects in platelet production, morphology, and function. The hematopoietic TFs implicated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27463948
DOI: 10.1080/09537104.2016.1203400
PMCID: PMC5628047

Genes

FLI1
GATA1
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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