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Inhibition of placental trophoblast fusion by guanylate-binding protein 5

7 May 2025

Abstract excerpt

Syncytin-1 and Syncytin-2 are envelope glycoproteins encoded by human endogenous retroviruses that have been exapted for the fusion of cytotrophoblast cells into syncytiotrophoblasts during placental development. Pregnancy complications like preeclampsia are associated with altered expression of interferon-stimulated genes, including guanylate-binding protein 5 (GBP5). Here, we show that misdirected antiviral...

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PMID: 40333975
DOI: 10.1126/sciadv.adt5388

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