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Regulation of human trophoblast syncytialization by histone demethylase LSD1

7 Oct 2019

Abstract excerpt

A successful pregnancy is critically dependent upon proper placental development and function. During human placentation, villous cytotrophoblast (CTB) progenitors differentiate to form syncytiotrophoblasts (SynTBs), which provide the exchange surface between the mother and fetus and secrete hormones to ensure proper progression of pregnancy. However, epigenetic mechanisms that regulate SynTB differentiation from...

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PMID: 31591264
DOI: 10.1074/jbc.ra119.010518

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