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Zika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoids

8 Sept 2023

Abstract excerpt

Zika virus (ZIKV) infection during pregnancy threatens pregnancy and fetal health. However, the infectivity and pathological effects of ZIKV on placental trophoblast progenitor cells in early human embryos remain largely unknown. Here, using human trophoblast stem cells (hTSCs), we demonstrated that hTSCs were permissive to ZIKV infection, and resistance to ZIKV increased with hTSC differentiation. Combining gene...

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PMID: 37684223
DOI: 10.1038/s41467-023-41158-0

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