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Article

Cold-inducible RNA-binding protein CIRP/hnRNP A18 regulates telomerase activity in a temperature-dependent manner

15 Dec 2015

Abstract excerpt

The telomerase is responsible for adding telomeric repeats to chromosomal ends and consists of the reverse transcriptase TERT and the RNA subunit TERC. The expression and activity of the telomerase are tightly regulated, and aberrant activation of the telomerase has been observed in >85% of human cancers. To better understand telomerase regulation, we performed immunoprecipitations coupled with mass spectrometry...

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Share to RNA Interference and Gene Delivery
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Share to Telomeres, Telomerase, and Senescence

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PMID: 26673712
DOI: 10.1093/nar/gkv1465

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