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Identification of genes involved in the regulation of TERT in hepatocellular carcinoma

17 Nov 2018

Abstract excerpt

Telomerase reverse transcriptase (TERT) promotes immortalization by protecting telomeres in cancer cells. Mutation of the TERT promoter is one of the most common genetic alterations in hepatocellular carcinoma (HCC), indicating that TERT upregulation is a critical event in hepatocarcinogenesis. Regulators of TERT transcription are, therefore, predicted to be plausible targets for HCC treatment. We undertook a...

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PMID: 30447097
DOI: 10.1111/cas.13884

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