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Comprehensive analyses of telomerase component DKC1 and its association with clinical, molecular and immune landscapes in uterine corpus endometrial carcinoma

19 May 2025

Abstract excerpt

Background: Telomerase activation is essential to malignant transformation and progression including uterine corpus endometrial carcinoma (UCEC), while telomerase co-factor DKC1-mediated RNA pseudouridylation is required for functional telomerase by stabilizing telomerase RNA component (TERC) and its upregulation occurs in many cancers. Surprisingly, there is only one publication studying DKC1 in UCEC, which...

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PMID: 40458122
DOI: 10.3389/fcell.2025.1592135

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