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Article

SPI1 activates TGF-β1/PI3K/Akt signaling through transcriptional upregulation of FKBP12 to support the mesenchymal phenotype of glioma stem cells.

Brain pathology (Zurich, Switzerland) - 1 May 2024

Song Yifu, Zhang Yaochuan, Wang Xiaoliang, Han Xiaodi, Shi Mengwu, Xu Ling, Yu Juanhan, Zhang Li, Han Sheng

Abstract excerpt

Glioma stem cells (GSCs) exhibit diverse molecular subtypes with the mesenchymal (MES) population representing the most malignant variant. The oncogenic potential of Salmonella pathogenicity island 1 (SPI1), an oncogenic transcription factor, has been established across various human malignancies. In this study, we explored the association between the SPI1 pathway and the MES GSC phenotype. Through comprehensive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37865975
DOI: 10.1111/bpa.13217
PMCID: PMC11007049

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