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The mammalian CTLH complex is an E3 ubiquitin ligase that targets its subunit muskelin for degradation

8 Jul 2019

Abstract excerpt

The multi-subunit C-terminal to LisH (CTLH) complex is the mammalian homologue of the yeast Gid E3 ubiquitin ligase complex. In this study, we investigated the human CTLH complex and characterized its E3 ligase activity. We confirm that the complex immunoprecipitated from human cells comprises RanBPM, ARMC8 α/β, muskelin, WDR26, GID4 and the RING domain proteins RMND5A and MAEA. We find that loss of expression of...

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PMID: 31285494
DOI: 10.1038/s41598-019-46279-5

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