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Article

Inhibition of HDAC6 activity through interaction with RanBPM and its associated CTLH complex.

BMC cancer - 1 Jul 2017

Salemi Louisa M, Maitland Matthew E R, Yefet Eyal R, Schild-Poulter Caroline

Abstract excerpt

BACKGROUND: Histone deacetylase 6 (HDAC6) is a microtubule-associated deacetylase that promotes many cellular processes that lead to cell transformation and tumour development. We previously documented an interaction between Ran-Binding Protein M (RanBPM) and HDAC6 and found that RanBPM expression inhibits HDAC6 activity. RanBPM is part of a putative E3 ubiquitin ligase complex, termed the C-terminal to LisH...

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Identifiers

PMID: 28668087
DOI: 10.1186/s12885-017-3430-2
PMCID: PMC5494137

Genes

HDAC6
MAEA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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