Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

1 Jul 2019

Abstract excerpt

BACKGROUND: Ageing-related failure of homeostasis mechanisms contributes to articular cartilage degeneration and osteoarthritis (OA), for which disease-modifying treatments are not available. Our objective was to identify molecules to prevent OA by regulating chondrocyte senescence and autophagy. METHODS: Human chondrocytes with IL-6 induced senescence and autophagy suppression and SA-β-gal as a reporter of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Osteoarthritis Treatment and Mechanisms
Share to Peroxisome Proliferator-Activated Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31285188
DOI: 10.1016/j.ebiom.2019.06.049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapyPMID 31285188Read ↗

The role of chondrocyte senescence in osteoarthritis pathogenesis and therapeutic implicationsSemantic proximity Read ↗

Cellular Aging, Senescence and Autophagy Processes in Osteoarthritis.Semantic proximity Read ↗

Role of the Inflammation-Autophagy-Senescence Integrative Network in OsteoarthritisSemantic proximity Read ↗

Mechanisms and therapeutic implications of cellular senescence in osteoarthritis.Semantic proximity Read ↗

Cellular senescence in osteoarthritis and anti-aging strategies.Semantic proximity Read ↗

Targeting cellular senescence as a novel treatment for osteoarthritis.Semantic proximity Read ↗

A Standardized In Vitro Platform for Senolytic Drug Discovery in Human Musculoskeletal CellsSemantic proximity Read ↗

Disrupting the Senescence-Associated Secretory Phenotype-M1Macrophage Feedback Loop in Synovitis Using Dual Nano-Switches To Restore Joint Homeostasis.Semantic proximity Read ↗

Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by the release of pro-anabolic mediators.Semantic proximity Read ↗

Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by promoting the release of pro-anabolic mediatorsSemantic proximity Read ↗

Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and cartilage regeneration in osteoarthritisSemantic proximity Read ↗

Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.