Article

Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by promoting the release of pro-anabolic mediators

2024-04-08

Abstract excerpt

Cellular senescence is associated with various age-related disorders and is assumed to play a major role in the pathogenesis of osteoarthritis (OA). Based on this, we tested a senolytic combination therapy using Dasatinib (D) and Quercetin (Q) on aged isolated human articular chondrocytes (hACs), as well as in OA-affected cartilage tissue (OARSI grade 1-2). Stimulation with D+Q selectively eliminated senescent cel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b4193e79-f9a7-5553-995e-843727f32ab2
DOI: 10.1101/2024.04.04.588076

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by promoting the release of pro-anabolic mediatorsDOI 10.1101/2024.04.04.588076Read

Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by the release of pro-anabolic mediators.Semantic proximity Read

Combined senolytics induce varied phenotypic and functional responses on senescent phenotypes of mesenchymal stromal cell populations.Semantic proximity Read

The role of chondrocyte senescence in osteoarthritis pathogenesis and therapeutic implicationsSemantic proximity Read

Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice.Semantic proximity Read

<i>In vitro</i> and <i>in vivo</i> effects of zoledronate on senescence and senescence-associated secretory phenotype markersSemantic proximity Read

Cellular senescence in osteoarthritis and anti-aging strategies.Semantic proximity Read

Eliminating senescent chondrogenic progenitor cells enhances chondrogenesis under intermittent hydrostatic pressure for the treatment of OASemantic proximity Read

Targeting senescent cells by dasatinib and quercetin ameliorates postmenopausal osteoporosis and rejuvenates bone regeneration.Semantic proximity Read

Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting SIRT6Semantic proximity Read

A single-cell mass cytometry platform to map the effects of preclinical drugs on cartilage homeostasisSemantic proximity Read

Targeting cellular senescence as a novel treatment for osteoarthritis.Semantic proximity Read

ESC-sEVs alleviate non-early-stage osteoarthritis progression by rejuvenating senescent chondrocytes via FOXO1A-autophagy axis but not inducing apoptosisSemantic proximity Read