Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RUNX3 suppresses metastasis and stemness by inhibiting Hedgehog signaling in colorectal cancer

5 Jul 2019

Abstract excerpt

Disabled tumor suppressor genes and hyperactive oncogenes greatly contribute to cell fates during cancer development because of their genetic alterations such as somatic mutations. However, little is known about how tumor suppressor genes react to diverse oncogenes during tumor progression. Our previous study showed that RUNX3 inhibits invasiveness by preventing vascular endothelial growth factor secretion and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Hedgehog Signaling Pathway Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31278361
DOI: 10.1038/s41418-019-0379-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RUNX3 suppresses metastasis and stemness by inhibiting Hedgehog signaling in colorectal cancerPMID 31278361Read ↗

RUNX1 regulates the proliferation and chemoresistance of colorectal cancer through the Hedgehog signaling pathwaySemantic proximity Read ↗

Molecular pathology of RUNX3 in human carcinogenesis.Semantic proximity Read ↗

RUNX3 in Stem Cell and Cancer Biology.Semantic proximity Read ↗

Inhibiting HMGCR represses stemness and metastasis of hepatocellular carcinoma via Hedgehog signalingSemantic proximity Read ↗

Restored expression of the tumor suppressor gene RUNX3 reduces cancer stem cells in hepatocellular carcinoma by suppressing Jagged1-Notch signalingSemantic proximity Read ↗

Hedgehog Gli3 activator signal augments tumorigenicity of colorectal cancer via upregulation of adherence-related genes.Semantic proximity Read ↗

PCGF1 promotes epigenetic activation of stemness markers and colorectal cancer stem cell enrichment.Semantic proximity Read ↗

RUNX3 in oncogenic and anti‐oncogenic signaling in gastrointestinal cancersSemantic proximity Read ↗

Context-dependent Regulation of the GLI Code in Cancer by HEDGEHOG and Non-HEDGEHOG SignalsSemantic proximity Read ↗

High expression of RUNX1 in colorectal cancer subtype accelerates malignancy by inhibiting HMGCRSemantic proximity Read ↗

Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.Semantic proximity Read ↗

RUNX family: Regulation and diversification of roles through interacting proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.