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Article

Hedgehog Gli3 activator signal augments tumorigenicity of colorectal cancer via upregulation of adherence-related genes.

Cancer science - 1 Mar 2013

Iwasaki Hironori, Nakano Kenji, Shinkai Kentaro, Kunisawa Yumi, Hirahashi Minako, Oda Yoshinao, Onishi Hideya, Katano Mitsuo

Abstract excerpt

Hedgehog signal is re-activated in several cancers. In this study, we examined the role of Gli3 on malignant phenotype of tumorigenicity for colorectal cancer and its relationship with p53, WNT and ERK/AKT signals. Gli3 expression was detected in HT29 and SW480 (p53-mutant) cells, but not in DLD-1 (p53-mutant) or HCT116 (p53-wild type) cells by reverse transcription-polymerase chain reaction and...

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Identifiers

PMID: 23176625
DOI: 10.1111/cas.12073
PMCID: PMC7657255

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DLD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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