Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Restored expression of the tumor suppressor gene RUNX3 reduces cancer stem cells in hepatocellular carcinoma by suppressing Jagged1-Notch signaling

31 May 2011

Abstract excerpt

Runt-related transcription factor 3 (RUNX3) is a candidate tumor suppressor gene that is downregulated in various cancers. In the present study, we analyzed the regulatory function of RUNX3 on Jagged-1 (JAG1) expression and cancer stem cell (CSC) signaling in hepatocellular carcinoma (HCC). Eleven HCC cell lines and 30 human HCC tissues were used. RUNX3 and JAG1 expression levels were analyzed by immunoblotting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21637926
DOI: 10.3892/or.2011.1336

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Restored expression of the tumor suppressor gene RUNX3 reduces cancer stem cells in hepatocellular carcinoma by suppressing Jagged1-Notch signalingPMID 21637926Read ↗

Multiple Roles of the RUNX Gene Family in Hepatocellular Carcinoma and Their Potential Clinical ImplicationsSemantic proximity Read ↗

Multiple Roles of RUNX Gene Family in Hepatocellular Carcinoma and Their Potential Clinical ImplicationsSemantic proximity Read ↗

RUNX3 suppresses metastasis and stemness by inhibiting Hedgehog signaling in colorectal cancerSemantic proximity Read ↗

Molecular pathology of RUNX3 in human carcinogenesis.Semantic proximity Read ↗

RUNX3 in Stem Cell and Cancer Biology.Semantic proximity Read ↗

Oncogenic role of RUNX3 in head and neck cancerSemantic proximity Read ↗

Overexpression of regenerating islet-derived 1 alpha and 3 alpha genes in human primary liver tumors with beta-catenin mutations.Semantic proximity Read ↗

Loss of runt-related transcription factor 3 expression leads hepatocellular carcinoma cells to escape apoptosis.Semantic proximity Read ↗

Notch and Wnt/β-catenin signaling pathway play important roles in activating liver cancer stem cellsSemantic proximity Read ↗

Inhibiting HMGCR represses stemness and metastasis of hepatocellular carcinoma via Hedgehog signalingSemantic proximity Read ↗

Decreased expression and frequent allelic inactivation of the RUNX3 gene at 1p36 in human hepatocellular carcinoma.Semantic proximity Read ↗

TGF-β1 induced deficiency of linc00261 promotes epithelial–mesenchymal-transition and stemness of hepatocellular carcinoma via modulating SMAD3Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.