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Targeting mutant p53 in cancer: the latest insights

5 Jul 2019

Abstract excerpt

This commentary wishes to highlight the latest discoveries in the mutant p53 field that have been discussed in the 8th p53 Mutant Workshop 2019, held in Lyon. TP53 mutant (mutp53) proteins are involved in the pathogenesis of most human cancers. Mutp53 proteins not only lose wild-typ53 function but, in some circumstances, may acquire novel oncogenic functions, namely gain-of-function (GOF), which lead to aberrant...

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PMID: 31277687
DOI: 10.1186/s13046-019-1302-0

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