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TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling

28 Jun 2019

Abstract excerpt

Cancer stem cells (CSCs) represent a major source of treatment resistance and tumor progression. However, regulation of CSCs stemness is not entirely understood. Here, we report that TSPAN8 expression is upregulated in breast CSCs, promotes the expression of the stemness gene NANOG, OCT4, and ALDHA1, and correlates with therapeutic resistance. Mechanistically, TSPAN8 interacts with PTCH1 and inhibits the...

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PMID: 31253779
DOI: 10.1038/s41467-019-10739-3

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