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Concise Review: NANOG in Cancer Stem Cells and Tumor Development: An Update and Outstanding Questions

27 Mar 2015

Abstract excerpt

The homeobox domain transcription factor NANOG, a key regulator of embryonic development and cellular reprogramming, has been reported to be broadly expressed in human cancers. Functional studies have provided strong evidence that NANOG possesses protumorigenic attributes. In addition to promoting self-renewal and long-term proliferative potential of stem-like cancer cells, NANOG-mediated oncogenic reprogramming...

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PMID: 25821200
DOI: 10.1002/stem.2007

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