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THOC2 and THOC5 Regulate Stemness and Radioresistance in Triple‐Negative Breast Cancer

27 Oct 2021

Abstract excerpt

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. Radioresistance and stemness are substantial obstacles to TNBC treatment. The THO complex (THOC) is a subunit of the TRanscription-EXport complex that functions in the coupling of transcription to nascent RNA splicing, elongation, and export. However, its role in regulating TNBC therapeutic resistance is not reported yet. In...

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PMID: 34708581
DOI: 10.1002/advs.202102658

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