Article

Aberrations in Notch-Hedgehog signalling reveal cancer stem cells harbouring conserved oncogenic properties associated with hypoxia and immunoevasion

2019-01-21

Abstract excerpt

<h4>Background: </h4> Cancer stem cells (CSCs) have innate abilities to resist even the harshest of therapies. To eradicate CSCs, parallels can be drawn from signalling modules that orchestrate pluripotency. Notch-Hedgehog hyperactivation are seen in CSCs, yet, not much is known about their conserved roles in tumour progression across cancers. <h4>Methods:</h4> Employing a comparative approach involving 21 cancers...

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Literature Corpus work: e9ba570c-6017-50d6-a0ce-71b9b1431726
DOI: 10.1101/526202

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