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Article

Filovirus Infection of STAT-1 Knockout Mice

10 Oct 2011

Abstract excerpt

We evaluated the susceptibility to Ebola and Marburg virus infection of mice that cannot respond to interferon (IFN)-α/β and IFN-γ because of deletion of the STAT-1 gene. A mouse-adapted Zaire ebolavirus (ZEBOV) caused rapidly lethal disease; wild-type ZEBOV and Sudan Ebolavirus and 4 different Marburg virus strains produced severe, but more slowly progressive illness; and Reston Ebolavirus caused mild disease...

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PMID: 21987780
DOI: 10.1093/infdis/jir335

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