Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A polymorphism of the TIM-1 IgV domain: implications for the susceptibility to filovirus infection.

Biochemical and biophysical research communications - 12 Dec 2014

Kuroda Makoto, Fujikura Daisuke, Noyori Osamu, Kajihara Masahiro, Maruyama Junki, Miyamoto Hiroko, Yoshida Reiko, Takada Ayato

Abstract excerpt

Filoviruses, including Ebola and Marburg viruses, cause severe hemorrhagic fever in humans and nonhuman primates with mortality rates of up to 90%. Human T-cell immunoglobulin and mucin domain 1 (TIM-1) is one of the host proteins that have been shown to promote filovirus entry into cells. In thi...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to COS Cells
Share to Green Fluorescent Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney

Share to Membrane Glycoproteins

Share to Mutagenesis

Share to Receptors, Virus

Share to Vero Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 25449273
DOI: 10.1016/j.bbrc.2014.10.144
PMCID: PMC7124303

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25449273-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A polymorphism of the TIM-1 IgV domain: implications for the susceptibility to filovirus infection.PMID 25449273Read ↗

TIM-family Proteins Promote Infection of Multiple Enveloped Viruses through Virion-associated PhosphatidylserineSemantic proximity Read ↗

TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelopeSemantic proximity Read ↗

TIM-1 serves as a receptor for Ebola virus in vivo, enhancing viremia and pathogenesisSemantic proximity Read ↗

TIM-1 Promotes Japanese Encephalitis Virus Entry and InfectionSemantic proximity Read ↗

Lineage-specific evolution of T-cell immunoglobulin and mucin domain 1 gene in the primates.Semantic proximity Read ↗

The ability of human TIM1 to bind phosphatidylethanolamine enhances viral uptake and efferocytosis compared to rhesus and mouse orthologsSemantic proximity Read ↗

P34L Mutation of swine TIM-1 enhances its ability to mediate Japanese encephalitis virus infection.Semantic proximity Read ↗

EBV BILF1 evolved to downregulate cell surface display of a wide range of HLA class I molecules through their cytoplasmic tail.Semantic proximity Read ↗

Single-Nucleotide Polymorphisms in Human NPC1 Influence Filovirus Entry Into Cells.Semantic proximity Read ↗

The Capacity of UL49.5 Proteins To Inhibit TAP Is Widely Distributed among Members of the Genus VaricellovirusSemantic proximity Read ↗

Polymorphisms in STING Affect Human Innate Immune Responses to Poxviruses.Semantic proximity Read ↗

Mutation of the Putative Immunosuppressive Domain of the Retroviral Envelope Glycoprotein Compromises Infectivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.