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Article

West Nile Virus Envelope Protein Inhibits dsRNA-Induced Innate Immune Responses

1 Dec 2007

Abstract excerpt

The immune response against viral infection relies on the early production of cytokines that induce an antiviral state and trigger the activation of immune cells. This response is initiated by the recognition of virus-associated molecular patterns such as dsRNA, a viral replication intermediate recognized by TLR3 and certain RNA helicases. Infection with West Nile virus (WNV) can lead to lethal encephalitis in...

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PMID: 18056386
DOI: 10.4049/jimmunol.179.12.8403

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