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WTAP Accelerates Exhaustion of CD8 + T Cells and Progression of Hepatocellular Carcinoma by Promoting m6A Modification and Translation of PD1 mRNA

1 Jan 2025

Abstract excerpt

The N6‐methyladenosine (m6A) methylase WTAP has been identified as a proto‐oncogene in multiple cancers, including hepatocellular carcinoma (HCC). Interestingly, although WTAP expression does not differ between normal liver and HCC tissues or across different stages of HCC, patients with higher WTAP expression exhibit significantly shorter median survival times (MSTs). Here, we found that WTAP was upregulated in...

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Galectins and Cancer Biology
Peptidase Inhibition and Analysis
RNA modifications and cancer

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40568348
DOI: 10.1155/mi/6217272

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