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Article

The Clinical Relevance of FTO as a Demethylase Beyond Cancer: Molecular Mechanisms and Therapeutic Opportunities.

Aging and disease - 10 Sept 2025

Guo Cun-Yang, Du Yi-Fei, Yan Hui-Cong, Fan Xin-Ming, Tian Fang-Qi, Xu Ping

Abstract excerpt

The fat mass and obesity-associated (FTO) gene is a key gene that has been linked to obesity and metabolic regulation. FTO single nucleotide polymorphisms (SNPs) significantly contribute to the pathophysiology of various multisystem diseases via epigenetic mechanisms. Although FTO has been extensively reviewed in the context of cancer, a comprehensive evaluation of its role in non-malignant diseases is currently...

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Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasms

Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 40956960
DOI: 10.14336/AD.2025.0916
PMCID: PMC13437108

Genes

FTO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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The Clinical Relevance of FTO as a Demethylase Beyond Cancer: Molecular Mechanisms and Therapeutic Opportunities.PMID 40956960Read ↗

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Dysregulation of ERAD and Stress Response Proteins by V493F FTO Over-expression: A Proteomic Perspective.Semantic proximity Read ↗

Fine-Scale Haplotype Mapping Reveals an Association of the FTO Gene with Osteoporosis and Fracture Risk in Postmenopausal Women.Semantic proximity Read ↗

In silico profiling of nonsynonymous SNPs of fat mass and obesity-associated gene: possible impacts on the treatment of non-alcoholic fatty liver disease.Semantic proximity Read ↗

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