Chromosome dynamics near the sol-gel phase transition dictate the timing of remote genomic interactions

Abstract excerpt

Abstract Diverse antibody repertoires are generated through remote genomic interactions involving immunoglobulin variable (V H ), diversity (D H ) and joining (J H ) gene segments. How such interactions are orchestrated remains unknown. Here we develop a strategy to track V H -D H J H motion in B-lymphocytes. We find that V H and D H J H segments are trapped in configurations that allow only local motion, such...

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