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Article

Controversies around epithelial-mesenchymal plasticity in cancer metastasis.

Nature reviews. Cancer - 1 Dec 2019

Williams Elizabeth D, Gao Dingcheng, Redfern Andrew, Thompson Erik W

Abstract excerpt

Experimental evidence accumulated over decades has implicated epithelial-mesenchymal plasticity (EMP), which collectively encompasses epithelial-mesenchymal transition and the reverse process of mesenchymal-epithelial transition, in tumour metastasis, cancer stem cell generation and maintenance, and therapeutic resistance. However, the dynamic nature of EMP processes, the apparent need to reverse mesenchymal...

Topics

Animals
Cell Line, Tumor
Cell Plasticity
Disease Progression
Drug Resistance, Neoplasm
Epithelial-Mesenchymal Transition
Humans
Immunotherapy
Mice
Neoplasm Invasiveness
Neoplasm Metastasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasms

Neoplastic Stem Cells

Phenotype

Rats

Source

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Identifiers

PMID: 31666716
DOI: 10.1038/s41568-019-0213-x
PMCID: PMC7055151

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