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Article

The role of junctophilin proteins in cellular function

10 Jan 2022

Abstract excerpt

Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR). Tethering of these membrane structures results in the formation of highly organized subcellular junctions that play important signaling roles in all excitable cell types. There are four JPH isoforms, expressed primarily in muscle and neuronal...

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PMID: 35001666
DOI: 10.1152/physrev.00024.2021

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