Article
Emerging role of junctophilin-2 as a regulator of calcium handling in the heart.
Acta pharmacologica Sinica - 1 Sept 2010
Garbino Alejandro, Wehrens Xander H T
Abstract excerpt
Junctophilin-2 (JPH2) is a membrane-binding protein that plays a key role in the organization of the junctional membrane complex (JMC) in cardiac myocytes. JPH2 is believed to keep the plasma membrane and sarcoplasmic reticulum at a fixed distance within the JMC, which is essential for proper Ca(2+)-induced Ca(2+) release during the excitation-contraction process. Recent studies have revealed that mutations in...
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