Impact of the hypoxia inducible factor-1α (HIF-1α) pro582ser polymorphism and its gene expression on diabetic foot ulcers.

doi:10.1016/j.diabres.2015.05.014

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Article

Impact of the hypoxia inducible factor-1α (HIF-1α) pro582ser polymorphism and its gene expression on diabetic foot ulcers.

Diabetes research and clinical practice - 1 Sept 2015

Pichu Sivakamasundari, Sathiyamoorthy Jayalalitha, Krishnamoorthy Ezhilarasi, Umapathy Dhamodharan, Viswanathan Vijay

Abstract excerpt

AIM: Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional induction of series of genes and the primary factor mediating this response is the hypoxia-inducible factor-1α. This study was designed in order to examine the HIF-1α gene polymorphism, p582s (rs11549465) in Exon-12 of HIF-1α gene in diabetic subjects with and without foot ulcers (DFU) and to find its expression...

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PMID: 26113285
DOI: 10.1016/j.diabres.2015.05.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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