Association of hypoxia inducible factor-1 alpha gene polymorphism with both type 1 and type 2 diabetes in a Caucasian (Hungarian) sample.

doi:10.1186/1471-2350-10-79

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Article

Association of hypoxia inducible factor-1 alpha gene polymorphism with both type 1 and type 2 diabetes in a Caucasian (Hungarian) sample.

BMC medical genetics - 19 Aug 2009

Nagy Geza, Kovacs-Nagy Reka, Kereszturi Eva, Somogyi Aniko, Szekely Anna, Nemeth Nora, Hosszufalusi Nora, Panczel Pal, Ronai Zsolt, Sasvari-Szekely Maria

Abstract excerpt

BACKGROUND: Hypoxia inducible factor-1 alpha (HIF-1alpha) is a transcription factor that plays an important role in neo-vascularisation, embryonic pancreas beta-cell mass development, and beta cell protection. Recently a non synonymous single nucleotide polymorphism (g.C45035T SNP, rs11549465) of HIF-1alpha gene, resulting in the p.P582S amino acid change has been shown to be associated with type 2 diabetes...

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PMID: 19691832
DOI: 10.1186/1471-2350-10-79
PMCID: PMC2736933

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