Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of hypoxia inducible factor-1 alpha exon 12 mutation in diabetic patients with and without diabetic foot ulcer.

International journal of biological macromolecules - 1 Nov 2018

Pichu Sivakamasundari, Vimalraj Selvaraj, Sathiyamoorthy Jayalalitha, Viswanathan Vijay

Abstract excerpt

Hypoxia inducible factor 1 alpha (HIF-1α) is a key regulator of the genes involved in the cellular response to hypoxia. This study aims to determine the HIF-1α gene polymorphism and its association with protein expression in diabetic subjects with and without diabetic foot ulcers (DFU). A total of 529 patients with T2DM (N = 185), DFU (N = 199) and Control (N = 145) were accounted for the study. PCR-RFLP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to Gene Expression

Share to Gene Frequency

Share to Genetic Association Studies

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Source

Identifiers

PMID: 30086330
DOI: 10.1016/j.ijbiomac.2018.08.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of hypoxia inducible factor-1 alpha exon 12 mutation in diabetic patients with and without diabetic foot ulcer.PMID 30086330Read ↗

Impact of the hypoxia inducible factor-1α (HIF-1α) pro582ser polymorphism and its gene expression on diabetic foot ulcers.Semantic proximity Read ↗

Genetic association of hypoxia inducible factor 1-alpha (HIF1A) Pro582Ser polymorphism with risk of diabetes and diabetic complications.Semantic proximity Read ↗

Correlation between polymorphisms of hypoxia-inducible factor-1α Pro582Ser and type 2 diabetic nephropathy.Semantic proximity Read ↗

Analysis of the Exonic Single Nucleotide Polymorphism rs182428269 of the NRF2 Gene in Patients with Diabetic Foot Ulcer.Semantic proximity Read ↗

Integrated genetic analysis of diabetic complications: Bioinformatics insights into foot ulcers, neuropathy and peripheral artery diseaseSemantic proximity Read ↗

Genetic Polymorphisms and the Risk of Diabetic Foot: A Systematic Review and Meta-Analyses.Semantic proximity Read ↗

Metabolic Memory in Diabetic Foot Syndrome (DFS): Epigenetic Changes of the Expression of Micro-rnas and Single Nucleotide Polymorphisms (SNPS) Frequency in a Cohort of Diabetic Patients With and Without Foot Ulceration and Correlation With Indices of Endothelial and Adipo-inflammatory DysfunctionSemantic proximity Read ↗

Genetic variation in the hypoxia-inducible factor-1alpha gene is associated with type 2 diabetes in Japanese.Semantic proximity Read ↗

Identification of angiogenesis-related genes in diabetic foot ulcer using machine learning algorithmsSemantic proximity Read ↗

Genetic Polymorphism of the Nrf2 Promoter Region (rs35652124) Is Associated with the Risk of Diabetic Foot Ulcers.Semantic proximity Read ↗

Association of MCP-1 rs1024611 polymorphism with diabetic foot ulcers.Semantic proximity Read ↗

Association of hypoxia inducible factor-1 alpha gene polymorphism with both type 1 and type 2 diabetes in a Caucasian (Hungarian) sample.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.