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Article

Genetic variation in the hypoxia-inducible factor-1alpha gene is associated with type 2 diabetes in Japanese.

The Journal of clinical endocrinology and metabolism - 1 Oct 2005

Yamada Norihiro, Horikawa Yukio, Oda Naohisa, Iizuka Katsumi, Shihara Nobuyuki, Kishi Shoji, Takeda Jun

Abstract excerpt

CONTEXT AND OBJECTIVE: Vascular endothelial growth factor plays a critical role both in neovascularization of proliferative diabetic retinopathy and in angiogenesis of islets in the pancreatic developmental stage in determining beta-cell mass and properties. Vascular endothelial growth factor mRNA levels increase as a result of increased transcriptional activation, mediated predominantly by hypoxia-inducible...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16046581
DOI: 10.1210/jc.2005-0991

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Genetic variation in the hypoxia-inducible factor-1alpha gene is associated with type 2 diabetes in Japanese.PMID 16046581Read ↗

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