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Contribution of DNA methylation to the expression of FCGRT in human liver and myocardium

17 Jun 2019

Abstract excerpt

FcRn mediates recycling and transcytosis of IgG and albumin in various cell types. The MHC-class-I-like protein of the FcRn heterodimer is encoded by FCGRT. Few determinants of variable FCGRT expression in humans have been identified so far. In this study, we investigated the presence of DNA methylation in regulatory regions of FCGRT in samples of human liver and myocardium tissue, and we examined the impact of...

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PMID: 31209240
DOI: 10.1038/s41598-019-45203-1

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