Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis.

doi:10.2133/dmpk.dmpk-10-rg-067

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Article

Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis.

Drug metabolism and pharmacokinetics - 1 Jan 2010

Ishii-Watabe Akiko, Saito Yoshiro, Suzuki Takuo, Tada Minoru, Ukaji Maho, Maekawa Keiko, Kurose Kouichi, Kaniwa Nahoko, Sawada Jun-ichi, Kawasaki Nana, Yamaguchi Teruhide, Nakajima Takako Eguchi, Kato Ken, Yamada Yasuhide, Shimada Yasuhiro, Yoshida Teruhiko, Ura Takashi, Saito Miyuki, Muro Kei, Doi Toshihiko, Fuse Nozomu, Yoshino Takayuki, Ohtsu Atsushi, Saijo Nagahiro, Hamaguchi Tetsuya, Okuda Haruhiro, Matsumura Yasuhiro

Abstract excerpt

Neonatal Fc receptor (FcRn) plays an important role in regulating IgG homeostasis in the body. Changes in FcRn expression levels or activity caused by genetic polymorphisms of FCGRT, which encodes FcRn, may lead to interindividual differences in pharmacokinetics of therapeutic antibodies. In this study, we sequenced the 5'-flanking region, all exons and their flanking regions of FCGRT from 126 Japanese subjects....

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PMID: 20930418
DOI: 10.2133/dmpk.dmpk-10-rg-067

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FCGRT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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