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Article

DNA methylation rather than single nucleotide polymorphisms regulates the production of an aberrant splice variant of IL6R in mastitic cows.

Cell stress & chaperones - 1 Jul 2018

Zhang Yan, Wang Xiuge, Jiang Qiang, Hao Haisheng, Ju Zhihua, Yang Chunhong, Sun Yan, Wang Changfa, Zhong Jifeng, Huang Jinming, Zhu Huabin

Abstract excerpt

Interleukin-6 receptor-alpha (IL6R) interacts with IL6 and forms a ligand-receptor complex, which can stimulate various cellular responses, such as cell proliferation, cell differentiation, and activation of inflammatory processes. Both genetic mutation and epigenetic modification regulate gene transcription. We identified a novel splice variant of bovine IL6R, designated as IL6R-TV, which is characterized by the...

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Identifiers

PMID: 29353404
DOI: 10.1007/s12192-017-0871-0
PMCID: PMC6045551

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