Article
Assessment of DNA methylation in porcine immune cells reveals novel regulatory elements associated with cell-specific gene expression and immune capacity traits.
BMC genomics - 11 Aug 2022
Corbett Ryan J, Luttman Andrea M, Herrera-Uribe Juber, Liu Haibo, Raney Nancy E, Grabowski Jenna M, Loving Crystal L, Tuggle Christopher K, Ernst Catherine W
Abstract excerpt
BACKGROUND: Genetics studies in the porcine immune system have enhanced selection practices for disease resistance phenotypes and increased the efficacy of porcine models in biomedical research; however limited functional annotation of the porcine immunome has hindered progress on both fronts. Among epigenetic mechanisms that regulate gene expression, DNA methylation is the most ubiquitous modification made to...
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