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Article

BRCA Mutations in Prostate Cancer: Assessment, Implications and Treatment Considerations.

International journal of molecular sciences - 23 Nov 2021

Shah Sidrah, Rachmat Rachelle, Enyioma Synthia, Ghose Aruni, Revythis Antonios, Boussios Stergios

Abstract excerpt

Prostate cancer ranks fifth in cancer-related mortality in men worldwide. DNA damage is implicated in cancer and DNA damage response (DDR) pathways are in place against this to maintain genomic stability. Impaired DDR pathways play a role in prostate carcinogenesis and germline or somatic mutations in DDR genes have been found in both primary and metastatic prostate cancer. Among these, BRCA mutations have been...

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Identifiers

PMID: 34884434
DOI: 10.3390/ijms222312628
PMCID: PMC8657599

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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