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Genetic Aberrations of DNA Repair Pathways in Prostate Cancer: Translation to the Clinic

10 Sept 2021

Abstract excerpt

Prostate cancer (PC) is the second most common cancer in men worldwide. Due to the large-scale sequencing efforts, there is currently a better understanding of the genomic landscape of PC. The identification of defects in DNA repair genes has led to clinical studies that provide a strong rationale for developing poly (ADP-ribose) polymerase (PARP) inhibitors and DNA-damaging agents in this molecularly defined...

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PMID: 34575947
DOI: 10.3390/ijms22189783

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