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Article

Therapeutic targeting of the DNA damage response in prostate cancer

10 Mar 2020

Abstract excerpt

PURPOSE OF REVIEW: The present article highlights the most common DNA repair gene mutations, using specific examples of individual genes or gene classes, and reviews the epidemiology and treatment implications for each one [with particular emphasis on poly-ADP-ribose polymerase (PARP) inhibition and PD-1 blockade]. RECENT FINDINGS: Genetic and genomic testing have an increasingly important role in the oncology...

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Identifiers

PMID: 32168038
DOI: 10.1097/cco.0000000000000617

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