Article
Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes.
The EMBO journal - 3 Mar 2003
Duraisingh Manoj T, Triglia Tony, Ralph Stuart A, Rayner Julian C, Barnwell John W, McFadden Geoffrey I, Cowman Alan F
Abstract excerpt
The members of the phylum Apicomplexa parasitize a wide range of eukaryotic host cells. Plasmodium falciparum, responsible for the most virulent form of malaria, invades human erythrocytes using several specific and high affinity ligand-receptor interactions that define invasion pathways. We find that members of the P. falciparum reticulocyte-binding homolog protein family, PfRh2a and PfRh2b, are expressed...
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