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An essential dual-function complex mediates erythrocyte invasion and channel-mediated nutrient uptake in malaria parasites

21 Feb 2017

Abstract excerpt

Malaria parasites evade immune detection by growth and replication within erythrocytes. After erythrocyte invasion, the intracellular pathogen must increase host cell uptake of nutrients from plasma. Here, we report that the parasite-encoded RhopH complex contributes to both invasion and channel-mediated nutrient uptake. As rhoph2 and rhoph3 gene knockouts were not viable in the human P. falciparum pathogen, we...

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PMID: 28221136
DOI: 10.7554/elife.23485

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