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Article

Lineage tracing and targeting of IL17RB + tuft cell-like human colorectal cancer stem cells

10 Jun 2019

Abstract excerpt

Significance Cancer stem cells, capable of self-renewing and giving rise to progeny cells in the tumor, have attracted attention as potential therapeutic targets. In this study, using genetically engineered mouse models, we showed that IL17RB, a tuft cell marker in the intestine, does not mark normal stem cells but marks tumor stem cells of mouse intestinal adenomas. Furthermore, using CRISPR-Cas9–mediated...

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PMID: 31182574
DOI: 10.1073/pnas.1900251116

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