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WWP2 ubiquitin ligase and its isoforms: New biological insight and promising disease targets

1 Aug 2011

Abstract excerpt

A number of recent papers on the WWP2 E3 ubiquitin ligase and two novel WWP2 isoforms have revealed important biological insight and disease-specific functions, and also impacted on our understanding of ubiquitin ligases in cell cycle regulation, apoptosis and differentiation. Gene knockout studies suggest a developmental role for WWP2 in chondrogenesis via mechanisms involving cartilage-specific transcription...

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PMID: 21750408
DOI: 10.4161/cc.10.15.16874

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