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Article

WWP2 confers risk to osteoarthritis by affecting cartilage matrix deposition via hypoxia associated genes

5 Oct 2022

Abstract excerpt

OBJECTIVE: To explore the co-expression network of the osteoarthritis (OA) risk gene WWP2 in articular cartilage and study cartilage characteristics when mimicking the effect of OA risk allele rs1052429-A on WWP2 expression in a human 3D in vitro model of cartilage. METHOD: Co-expression behavior of WWP2 with genes expressed in lesioned OA articular cartilage (N = 35 samples) was explored. By applying lentiviral...

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PMID: 36208715
DOI: 10.1016/j.joca.2022.09.009

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