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Article

Intratumoral Cell Heterogeneity in Patient-Derived Glioblastoma Cell Lines Revealed by Single-Cell RNA-Sequencing.

International journal of molecular sciences - 2 Aug 2024

Arbatskiy Mikhail, Balandin Dmitriy, Churov Alexey, Varachev Vyacheslav, Nikolaeva Eugenia, Mitrofanov Alexei, Bekyashev Ali, Tkacheva Olga, Susova Olga, Nasedkina Tatiana

Abstract excerpt

Glioblastoma cell lines derived from different patients are widely used in tumor biology research and drug screening. A key feature of glioblastoma is the high level of inter- and intratumor heterogeneity that accounts for treatment resistance. Our aim was to investigate whether intratumor heterogeneity is maintained in cell models. Single-cell RNA sequencing was used to investigate the cellular composition of a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39126040
DOI: 10.3390/ijms25158472
PMCID: PMC11313325

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