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Article

MiRNA-375 promotes beta pancreatic differentiation in human induced pluripotent stem (hiPS) cells.

Molecular biology reports - 1 Jan 2014

Lahmy Reyhaneh, Soleimani Masoud, Sanati Mohammad H, Behmanesh Mehrdad, Kouhkan Fatemeh, Mobarra Naser

Abstract excerpt

Islet transplantation is considered as an ultimate option for the treatment of type I diabetes. Human induced pluripotent stem cells (hiPSCs) have raised the possibility that patient-specific insulin-secreting cells might be derived from somatic cells through cell fate reprogramming. However, current protocols mostly rely on the use of several cytokines and inhibitors for directing differentiation towards...

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PMID: 24469711
DOI: 10.1007/s11033-014-3054-4

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